Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology

Identification and characterization of molecular mechanisms that connect genetic risk factors to initiation and evolution of disease pathophysiology represent major goals and opportunities for improving therapeutic and diagnostic outcomes in Alzheimer's disease (AD). Integrative genomic analysi...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Readhead, B, Haure-Mirande, J-V, Zhang, B, Haroutunian, V, Gandy, S, Schadt, E E, Dudley, J T, Ehrlich, M E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862938/
https://ncbi.nlm.nih.gov/pubmed/26552589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.167
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