Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology

Identification and characterization of molecular mechanisms that connect genetic risk factors to initiation and evolution of disease pathophysiology represent major goals and opportunities for improving therapeutic and diagnostic outcomes in Alzheimer's disease (AD). Integrative genomic analysi...

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Detalles Bibliográficos
Publicado en:Mol Psychiatry
Main Authors: Readhead, B, Haure-Mirande, J-V, Zhang, B, Haroutunian, V, Gandy, S, Schadt, E E, Dudley, J T, Ehrlich, M E
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862938/
https://ncbi.nlm.nih.gov/pubmed/26552589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.167
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