A mechanism for expansion of regulatory T cell repertoire and its role in self tolerance

T cell receptor (TCR) signaling plays a key role in T cell fate determination. Precursor cells expressing TCRs within a certain low affinity range for self peptide-MHC complexes undergo positive selection and differentiate into naïve T cells expressing a highly diverse self-MHC restricted TCR repert...

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Pubblicato in:Nature
Autori principali: Feng, Yongqiang, van der Veeken, Joris, Shugay, Mikhail, Putintseva, Ekaterina V, Osmanbeyoglu, Hatice U, Dikiy, Stanislav, Hoyos, Beatrice E, Moltedo, Bruno, Hemmers, Saskia, Treuting, Piper, Leslie, Christina S, Chudakov, Dmitriy M, Rudensky, Alexander Y
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862833/
https://ncbi.nlm.nih.gov/pubmed/26605529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16141
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