A mechanism for expansion of regulatory T cell repertoire and its role in self tolerance

T cell receptor (TCR) signaling plays a key role in T cell fate determination. Precursor cells expressing TCRs within a certain low affinity range for self peptide-MHC complexes undergo positive selection and differentiate into naïve T cells expressing a highly diverse self-MHC restricted TCR repert...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Feng, Yongqiang, van der Veeken, Joris, Shugay, Mikhail, Putintseva, Ekaterina V, Osmanbeyoglu, Hatice U, Dikiy, Stanislav, Hoyos, Beatrice E, Moltedo, Bruno, Hemmers, Saskia, Treuting, Piper, Leslie, Christina S, Chudakov, Dmitriy M, Rudensky, Alexander Y
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862833/
https://ncbi.nlm.nih.gov/pubmed/26605529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16141
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