A mechanism for expansion of regulatory T cell repertoire and its role in self tolerance

T cell receptor (TCR) signaling plays a key role in T cell fate determination. Precursor cells expressing TCRs within a certain low affinity range for self peptide-MHC complexes undergo positive selection and differentiate into naïve T cells expressing a highly diverse self-MHC restricted TCR repert...

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Dades bibliogràfiques
Publicat a:Nature
Autors principals: Feng, Yongqiang, van der Veeken, Joris, Shugay, Mikhail, Putintseva, Ekaterina V, Osmanbeyoglu, Hatice U, Dikiy, Stanislav, Hoyos, Beatrice E, Moltedo, Bruno, Hemmers, Saskia, Treuting, Piper, Leslie, Christina S, Chudakov, Dmitriy M, Rudensky, Alexander Y
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862833/
https://ncbi.nlm.nih.gov/pubmed/26605529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16141
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