A mechanism for expansion of regulatory T cell repertoire and its role in self tolerance

T cell receptor (TCR) signaling plays a key role in T cell fate determination. Precursor cells expressing TCRs within a certain low affinity range for self peptide-MHC complexes undergo positive selection and differentiate into naïve T cells expressing a highly diverse self-MHC restricted TCR repert...

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Published in:Nature
Main Authors: Feng, Yongqiang, van der Veeken, Joris, Shugay, Mikhail, Putintseva, Ekaterina V, Osmanbeyoglu, Hatice U, Dikiy, Stanislav, Hoyos, Beatrice E, Moltedo, Bruno, Hemmers, Saskia, Treuting, Piper, Leslie, Christina S, Chudakov, Dmitriy M, Rudensky, Alexander Y
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862833/
https://ncbi.nlm.nih.gov/pubmed/26605529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16141
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