Post-translational Transformation of Methionine to Aspartate Is Catalyzed by Heme Iron and Driven by Peroxide: A NOVEL SUBUNIT-SPECIFIC MECHANISM IN HEMOGLOBIN

A pathogenic V67M mutation occurs at the E11 helical position within the heme pockets of variant human fetal and adult hemoglobins (Hb). Subsequent post-translational modification of Met to Asp was reported in γ subunits of human fetal Hb Toms River (γ67(E11)Val → Met) and β subunits of adult Hb (Hb...

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Udgivet i:J Biol Chem
Main Authors: Strader, Michael Brad, Hicks, Wayne A., Kassa, Tigist, Singleton, Eileen, Soman, Jayashree, Olson, John S., Weiss, Mitchell J., Mollan, Todd L., Wilson, Michael T., Alayash, Abdu I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862693/
https://ncbi.nlm.nih.gov/pubmed/24939847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568980
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