Post-translational Transformation of Methionine to Aspartate Is Catalyzed by Heme Iron and Driven by Peroxide: A NOVEL SUBUNIT-SPECIFIC MECHANISM IN HEMOGLOBIN

A pathogenic V67M mutation occurs at the E11 helical position within the heme pockets of variant human fetal and adult hemoglobins (Hb). Subsequent post-translational modification of Met to Asp was reported in γ subunits of human fetal Hb Toms River (γ67(E11)Val → Met) and β subunits of adult Hb (Hb...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Strader, Michael Brad, Hicks, Wayne A., Kassa, Tigist, Singleton, Eileen, Soman, Jayashree, Olson, John S., Weiss, Mitchell J., Mollan, Todd L., Wilson, Michael T., Alayash, Abdu I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862693/
https://ncbi.nlm.nih.gov/pubmed/24939847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568980
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares