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Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects
Sickle cell disease (SCD) is an inherited blood disorder caused by a β globin gene mutation of hemoglobin (HbS). The polymerization of deoxyHbS and its subsequent aggregation (into long fibers) is the primary molecular event which leads to red blood cell (RBC) sickling and ultimately hemolytic anemi...
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| Publicado no: | Metallomics |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5607114/ https://ncbi.nlm.nih.gov/pubmed/28770911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7mt00104e |
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