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Histopathological Defects in Intestine in Severe Spinal Muscular Atrophy Mice Are Improved by Systemic Antisense Oligonucleotide Treatment

Gastrointestinal (GI) defects, including gastroesophageal reflux, constipation and delayed gastric emptying, are common in patients with spinal muscular atrophy (SMA). Similar GI dysmotility has been identified in mouse models with survival of motor neuron (SMN) protein deficiency. We previously des...

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發表在:PLoS One
Main Authors: Sintusek, Palittiya, Catapano, Francesco, Angkathunkayul, Napat, Marrosu, Elena, Parson, Simon H., Morgan, Jennifer E., Muntoni, Francesco, Zhou, Haiyan
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862622/
https://ncbi.nlm.nih.gov/pubmed/27163330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155032
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