Bidirectional Transfer of Raltegravir in an Ex Vivo Human Cotyledon Perfusion Model

Placental transfer of the HIV integrase inhibitor raltegravir (RLT) was investigated in term human cotyledons in the maternal-to-fetal (n = 3) and fetal-to-maternal (n = 6) directions. In the maternal-to-fetal direction, the mean ± standard deviation (SD) fetal transfer rate (FTR) was 9.1% ± 1.4%, a...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Vinot, Cécile, Tréluyer, Jean-Marc, Giraud, Carole, Gavard, Laurent, Peytavin, Gilles, Mandelbrot, Laurent
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862479/
https://ncbi.nlm.nih.gov/pubmed/26833154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00007-16
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