Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas

PURPOSE: Plexiform neurofibromas (pNF) are pathognomonic nerve and soft tissue tumors of neurofibromatosis type I (NF1), which are highly resistant to conventional chemotherapy and associated with significant morbidity/mortality. Disruption of aberrant SCF/c-Kit signaling emanating from the pNF micr...

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Publicado en:Pediatr Blood Cancer
Autores principales: Ferguson, Michael J., Rhodes, Steven D., Jiang, Li, Li, Xiaohong, Yuan, Jin, Yang, Xianlin, Zhang, Shaobo, Vakili, Saeed T., Territo, Paul, Hutchins, Gary, Yang, Feng-Chun, Ingram, David A., Clapp, D. Wade, Chen, Shi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862309/
https://ncbi.nlm.nih.gov/pubmed/26375012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25763
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