Early Administration of Imatinib Mesylate Reduces Plexiform Neurofibroma Tumor Burden with Durable Results after Drug Discontinuation in a Mouse Model of Neurofibromatosis Type 1

BACKGROUND: Neurofibromatosis type 1 (NF1) is a common genetic disorder characterized by plexiform neurofibromas (pNF), which are thought to be congenital tumors that arise in utero and enlarge throughout life. Genetic studies in murine models delineated an indispensable role for the stem cell facto...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Armstrong, Amy E., Rhodes, Steven D., Smith, Abbi, Chen, Shi, Bessler, Waylan, Ferguson, Michael J., Jiang, Li, Li, Xiaohong, Yuan, Jin, Yang, Xianlin, Yang, Feng-Chun, Robertson, Kent A., Ingram, David A., Blakeley, Jaishri O., Clapp, D. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7516834/
https://ncbi.nlm.nih.gov/pubmed/32459399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.28372
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