Endogenous and synthetic ABHD5 ligands regulate ABHD5-Perilipin interactions and lipolysis in fat and muscle

Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is...

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Publicat a:Cell Metab
Autors principals: Sanders, Matthew A., Madoux, Franck, Mladenovic, Ljiljana, Zhang, Huamei, Ye, Xiangqun, Angrish, Michelle, Mottillo, Emilio P., Caruso, Joseph A., Halvorsen, Geoff, Roush, William R., Chase, Peter, Hodder, Peter, Granneman, James G.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862007/
https://ncbi.nlm.nih.gov/pubmed/26411340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.08.023
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