Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs

Age-associated decline in organ function governs life span. We determined the effect of aging on lung function and cellular/molecular changes of 8- to 32-month old mice. Proteomic analysis of lung matrix indicated significant compositional changes with advanced age consistent with a profibrotic envi...

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Detalles Bibliográficos
Publicado en:J Gerontol A Biol Sci Med Sci
Main Authors: Calhoun, Cheresa, Shivshankar, Pooja, Saker, Mirna, Sloane, Lauren B., Livi, Carolina B., Sharp, Zelton D., Orihuela, Carlos J., Adnot, Serge, White, Eric S., Richardson, Arlan, Jourdan Le Saux, Claude
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861645/
https://ncbi.nlm.nih.gov/pubmed/25568097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glu241
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