Allosteric Inhibition of Bcr-Abl Kinase by High Affinity Monobody Inhibitors Directed to the Src Homology 2 (SH2)-Kinase Interface

Bcr-Abl is a constitutively active kinase that causes chronic myelogenous leukemia. We have shown that a tandem fusion of two designed binding proteins, termed monobodies, directed to the interaction interface between the Src homology 2 (SH2) and kinase domains and to the phosphotyrosine-binding sit...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wojcik, John, Lamontanara, Allan Joaquim, Grabe, Grzegorz, Koide, Akiko, Akin, Louesa, Gerig, Barbara, Hantschel, Oliver, Koide, Shohei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861451/
https://ncbi.nlm.nih.gov/pubmed/26912659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.707901
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