An Intrinsically Disordered Motif Mediates Diverse Actions of Monomeric C-reactive Protein

Most proinflammatory actions of C-reactive protein (CRP) are only expressed following dissociation of its native pentameric assembly into monomeric form (mCRP). However, little is known about what underlies the greatly enhanced activities of mCRP. Here we show that a single sequence motif, i.e. chol...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Li, Hai-Yun, Wang, Jing, Meng, Fan, Jia, Zhe-Kun, Su, Yang, Bai, Qi-Feng, Lv, Ling-Ling, Ma, Fu-Rong, Potempa, Lawrence A., Yan, Yong-Bin, Ji, Shang-Rong, Wu, Yi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861447/
https://ncbi.nlm.nih.gov/pubmed/26907682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695023
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