Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation

C-reactive protein (CRP) is an established marker of rheumatoid arthritis (RA) but with ill-defined actions in the pathogenesis. Here, we show that CRP regulates the differentiation of osteoclasts, a central mediator of joint inflammation and bone erosion in RA, in a conformation- and receptor activ...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jia, Zhe-Kun, Li, Hai-Yun, Liang, Yu-Lin, Potempa, Lawrence Albert, Ji, Shang-Rong, Wu, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827540/
https://ncbi.nlm.nih.gov/pubmed/29520264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00234
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