A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening

We performed a fragment screen on the dengue virus serotype 3 RNA-dependent RNA polymerase using x-ray crystallography. A screen of 1,400 fragments in pools of eight identified a single hit that bound in a novel pocket in the protein. This pocket is located in the polymerase palm subdomain and conse...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Noble, Christian G., Lim, Siew Pheng, Arora, Rishi, Yokokawa, Fumiaki, Nilar, Shahul, Seh, Cheah Chen, Wright, S. Kirk, Benson, Timothy E., Smith, Paul W., Shi, Pei-Yong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861426/
https://ncbi.nlm.nih.gov/pubmed/26872970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.710731
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