P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes

Type 1 diabetes (T1D) causes a range of skeletal problems, including reduced bone density and increased risk for bone fractures. However, mechanisms underlying skeletal complications in diabetes are still not well understood. We hypothesize that high glucose levels in T1D alters expression and funct...

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Veröffentlicht in:PLoS One
Hauptverfasser: Seref-Ferlengez, Zeynep, Maung, Stephanie, Schaffler, Mitchell B., Spray, David C., Suadicani, Sylvia O., Thi, Mia M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861344/
https://ncbi.nlm.nih.gov/pubmed/27159053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155107
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