Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study

BACKGROUND: Defining optimal routes for induction of mucosal immunity represents an important research priority for the HIV-1 vaccine field. In particular, it remains unclear whether mucosal routes of immunization can improve mucosal immune responses. METHODS: In this randomized two center phase I c...

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Udgivet i:PLoS One
Main Authors: Cosgrove, Catherine A., Lacey, Charles J., Cope, Alethea V., Bartolf, Angela, Morris, Georgina, Yan, Celine, Baden, Susan, Cole, Tom, Carter, Darrick, Brodnicki, Elizabeth, Shen, Xiaoying, Joseph, Sarah, DeRosa, Stephen C., Peng, Lili, Yu, Xuesong, Ferrari, Guido, Seaman, Mike, Montefiori, David C., Frahm, Nicole, Tomaras, Georgia D., Stöhr, Wolfgang, McCormack, Sheena, Shattock, Robin J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861263/
https://ncbi.nlm.nih.gov/pubmed/27159166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152038
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