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Klenow Fragment Discriminates Against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA

Defining the biological consequences of oxidative DNA damage remains an important and ongoing area of investigation. At the foundation of understanding the repercussions of such damage is a molecular-level description of the action of DNA-processing enzymes, such as polymerases. In this work we focu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Res Toxicol
Main Authors: Huang, Ji, Yennie, Craig J., Delaney, Sarah
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861072/
https://ncbi.nlm.nih.gov/pubmed/26572218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00330
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