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Klenow Fragment Discriminates Against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA

Defining the biological consequences of oxidative DNA damage remains an important and ongoing area of investigation. At the foundation of understanding the repercussions of such damage is a molecular-level description of the action of DNA-processing enzymes, such as polymerases. In this work we focu...

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Détails bibliographiques
Publié dans:Chem Res Toxicol
Auteurs principaux: Huang, Ji, Yennie, Craig J., Delaney, Sarah
Format: Artigo
Langue:Inglês
Publié: 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861072/
https://ncbi.nlm.nih.gov/pubmed/26572218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00330
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