HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on host membrane trafficking and receptor downregulation. By an unidentified mechanism, Nef increases the intrinsic infectivity of HIV-1 virions in a host-cell-dependent manner. Here we identify the host trans...

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Udgivet i:Nature
Main Authors: Rosa, Annachiara, Chande, Ajit, Ziglio, Serena, Sanctis, Veronica De, Bertorelli, Roberto, Goh, Shih Lin, McCauley, Sean M., Nowosielska, Anetta, Antonarakis, Stylianos E., Luban, Jeremy, Santoni, Federico Andrea, Pizzato, Massimo
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861059/
https://ncbi.nlm.nih.gov/pubmed/26416734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15399
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