Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis

Despite decades of intense global effort, no disease-modifying drugs for Alzheimer’s disease have emerged. Molecules targeting catalytic activities of γ-secretase or β-site APP-cleaving enzyme 1 (BACE1) have been beset by undesired side effects. We hypothesized that blocking the interaction between...

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Detalles Bibliográficos
Publicado en:Cell Discov
Main Authors: Cui, Jin, Wang, Xiaoyin, Li, Xiaohang, Wang, Xin, Zhang, Chenlu, Li, Wei, Zhang, Yangming, Gu, Haifeng, Xie, Xin, Nan, Fajun, Zhao, Jian, Pei, Gang
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860824/
https://ncbi.nlm.nih.gov/pubmed/27462420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.21
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