An Anti-Parkinson’s Disease Drug via Targeting Adenosine A(2A) Receptor Enhances Amyloid-β Generation and γ-Secretase Activity

γ-secretase mediates the intramembranous proteolysis of amyloid precursor protein (APP) and determines the generation of Aβ which is associated with Alzheimer’s disease (AD). Here we identified that an anti-Parkinson’s disease drug, Istradefylline, could enhance Aβ generation in various cell lines a...

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Publicado en:PLoS One
Autores principales: Lu, Jing, Cui, Jin, Li, Xiaohang, Wang, Xin, Zhou, Yue, Yang, Wenjuan, Chen, Ming, Zhao, Jian, Pei, Gang
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106031/
https://ncbi.nlm.nih.gov/pubmed/27835671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166415
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