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An Anti-Parkinson’s Disease Drug via Targeting Adenosine A(2A) Receptor Enhances Amyloid-β Generation and γ-Secretase Activity
γ-secretase mediates the intramembranous proteolysis of amyloid precursor protein (APP) and determines the generation of Aβ which is associated with Alzheimer’s disease (AD). Here we identified that an anti-Parkinson’s disease drug, Istradefylline, could enhance Aβ generation in various cell lines a...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5106031/ https://ncbi.nlm.nih.gov/pubmed/27835671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166415 |
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