Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone

The meiotic cell cycle of mammalian oocytes starts during embryogenesis and then pauses until luteinizing hormone (LH) acts on the granulosa cells of the follicle surrounding the oocyte to restart the cell cycle. An essential event in this process is a decrease in cyclic GMP in the granulosa cells,...

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Udgivet i:Dev Biol
Main Authors: Shuhaibar, Leia C., Egbert, Jeremy R., Edmund, Aaron B., Uliasz, Tracy F., Dickey, Deborah M., Yee, Siu-Pok, Potter, Lincoln R., Jaffe, Laurinda A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860734/
https://ncbi.nlm.nih.gov/pubmed/26522847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.10.025
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