Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

Activating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 guanylyl cyclase both cause severe short stature, but how these two signaling systems interact to regulate bone growth is poorly understood. Here, we show that bone elongation is increased when N...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Shuhaibar, Leia C, Robinson, Jerid W, Vigone, Giulia, Shuhaibar, Ninna P, Egbert, Jeremy R, Baena, Valentina, Uliasz, Tracy F, Kaback, Deborah, Yee, Siu-Pok, Feil, Robert, Fisher, Melanie C, Dealy, Caroline N, Potter, Lincoln R, Jaffe, Laurinda A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745078/
https://ncbi.nlm.nih.gov/pubmed/29199951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31343
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