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Mechanistic Analysis of the Effect of Deamidation on the Immunogenicity of Anthrax Protective Antigen
The spontaneous modification of proteins, such as deamidation of asparagine residues, can significantly affect the immunogenicity of protein-based vaccines. Using a “genetically deamidated” form of recombinant protective antigen (rPA), we have previously shown that deamidation can decrease the immun...
Tallennettuna:
| Julkaisussa: | Clin Vaccine Immunol |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Microbiology
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860472/ https://ncbi.nlm.nih.gov/pubmed/26912784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00701-15 |
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