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Mechanistic Analysis of the Effect of Deamidation on the Immunogenicity of Anthrax Protective Antigen

The spontaneous modification of proteins, such as deamidation of asparagine residues, can significantly affect the immunogenicity of protein-based vaccines. Using a “genetically deamidated” form of recombinant protective antigen (rPA), we have previously shown that deamidation can decrease the immun...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Vaccine Immunol
Hauptverfasser: Verma, Anita, Ngundi, Miriam M., Burns, Drusilla L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860472/
https://ncbi.nlm.nih.gov/pubmed/26912784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00701-15
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