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Mechanistic Analysis of the Effect of Deamidation on the Immunogenicity of Anthrax Protective Antigen
The spontaneous modification of proteins, such as deamidation of asparagine residues, can significantly affect the immunogenicity of protein-based vaccines. Using a “genetically deamidated” form of recombinant protective antigen (rPA), we have previously shown that deamidation can decrease the immun...
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| 出版年: | Clin Vaccine Immunol |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860472/ https://ncbi.nlm.nih.gov/pubmed/26912784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00701-15 |
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