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Mechanistic Analysis of the Effect of Deamidation on the Immunogenicity of Anthrax Protective Antigen
The spontaneous modification of proteins, such as deamidation of asparagine residues, can significantly affect the immunogenicity of protein-based vaccines. Using a “genetically deamidated” form of recombinant protective antigen (rPA), we have previously shown that deamidation can decrease the immun...
Gorde:
| Argitaratua izan da: | Clin Vaccine Immunol |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Society for Microbiology
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4860472/ https://ncbi.nlm.nih.gov/pubmed/26912784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00701-15 |
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