Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet‐Induced Metabolic Heart Disease

BACKGROUND: Mitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. METHODS AND RESULTS: Mice fed a high‐fat high‐sucrose (HFHS)...

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Bibliografische gegevens
Gepubliceerd in:J Am Heart Assoc
Hoofdauteurs: Sverdlov, Aaron L., Elezaby, Aly, Qin, Fuzhong, Behring, Jessica B., Luptak, Ivan, Calamaras, Timothy D., Siwik, Deborah A., Miller, Edward J., Liesa, Marc, Shirihai, Orian S., Pimentel, David R., Cohen, Richard A., Bachschmid, Markus M., Colucci, Wilson S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859372/
https://ncbi.nlm.nih.gov/pubmed/26755553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002555
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