Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet‐Induced Metabolic Heart Disease

BACKGROUND: Mitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. METHODS AND RESULTS: Mice fed a high‐fat high‐sucrose (HFHS)...

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Bibliografske podrobnosti
izdano v:J Am Heart Assoc
Main Authors: Sverdlov, Aaron L., Elezaby, Aly, Qin, Fuzhong, Behring, Jessica B., Luptak, Ivan, Calamaras, Timothy D., Siwik, Deborah A., Miller, Edward J., Liesa, Marc, Shirihai, Orian S., Pimentel, David R., Cohen, Richard A., Bachschmid, Markus M., Colucci, Wilson S.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859372/
https://ncbi.nlm.nih.gov/pubmed/26755553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002555
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