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Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet‐Induced Metabolic Heart Disease

BACKGROUND: Mitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. METHODS AND RESULTS: Mice fed a high‐fat high‐sucrose (HFHS)...

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Библиографические подробности
Опубликовано в: :J Am Heart Assoc
Главные авторы: Sverdlov, Aaron L., Elezaby, Aly, Qin, Fuzhong, Behring, Jessica B., Luptak, Ivan, Calamaras, Timothy D., Siwik, Deborah A., Miller, Edward J., Liesa, Marc, Shirihai, Orian S., Pimentel, David R., Cohen, Richard A., Bachschmid, Markus M., Colucci, Wilson S.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859372/
https://ncbi.nlm.nih.gov/pubmed/26755553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002555
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