Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge

BACKGROUND: Myocardial hypertrophy and dysfunction are key features of metabolic heart disease due to dietary excess. Metabolic heart disease manifests primarily as diastolic dysfunction but may progress to systolic dysfunction, although the mechanism is poorly understood. Liver kinase B1 (LKB1) is...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Miller, Edward J., Calamaras, Timothy, Elezaby, Aly, Sverdlov, Aaron, Qin, Fuzhong, Luptak, Ivan, Wang, Ke, Sun, Xinxin, Vijay, Andrea, Croteau, Dominique, Bachschmid, Markus, Cohen, Richard A., Walsh, Kenneth, Colucci, Wilson S.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859355/
https://ncbi.nlm.nih.gov/pubmed/26722122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002277
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