Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge

BACKGROUND: Myocardial hypertrophy and dysfunction are key features of metabolic heart disease due to dietary excess. Metabolic heart disease manifests primarily as diastolic dysfunction but may progress to systolic dysfunction, although the mechanism is poorly understood. Liver kinase B1 (LKB1) is...

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Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Miller, Edward J., Calamaras, Timothy, Elezaby, Aly, Sverdlov, Aaron, Qin, Fuzhong, Luptak, Ivan, Wang, Ke, Sun, Xinxin, Vijay, Andrea, Croteau, Dominique, Bachschmid, Markus, Cohen, Richard A., Walsh, Kenneth, Colucci, Wilson S.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859355/
https://ncbi.nlm.nih.gov/pubmed/26722122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.002277
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