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Triallelic Population Genomics for Inferring Correlated Fitness Effects of Same Site Nonsynonymous Mutations

The distribution of mutational effects on fitness is central to evolutionary genetics. Typical univariate distributions, however, cannot model the effects of multiple mutations at the same site, so we introduce a model in which mutations at the same site have correlated fitness effects. To infer the...

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Detaylı Bibliyografya
Yayımlandı:Genetics
Asıl Yazarlar: Ragsdale, Aaron P., Coffman, Alec J., Hsieh, PingHsun, Struck, Travis J., Gutenkunst, Ryan N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Genetics Society of America 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858796/
https://ncbi.nlm.nih.gov/pubmed/27029732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.115.184812
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