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Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantification of Selection on Nonsynonymous and Synonymous Sites in Humans
Sequencing errors and random sampling of nucleotide types among sequencing reads at heterozygous sites present challenges for accurate, unbiased inference of single-nucleotide polymorphism genotypes from high-throughput sequence data. Here, we develop a maximum-likelihood approach to estimate the fr...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Genetics Society of America
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3176106/ https://ncbi.nlm.nih.gov/pubmed/21596896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.128355 |
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