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Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantification of Selection on Nonsynonymous and Synonymous Sites in Humans

Sequencing errors and random sampling of nucleotide types among sequencing reads at heterozygous sites present challenges for accurate, unbiased inference of single-nucleotide polymorphism genotypes from high-throughput sequence data. Here, we develop a maximum-likelihood approach to estimate the fr...

詳細記述

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書誌詳細
主要な著者: Keightley, Peter D., Halligan, Daniel L.
フォーマット: Artigo
言語:Inglês
出版事項: Genetics Society of America 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176106/
https://ncbi.nlm.nih.gov/pubmed/21596896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.128355
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