Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17

Limited proteolysis of the Interleukin-6 Receptor (IL-6R) leads to the release of the IL-6R ectodomain. Binding of the cytokine IL-6 to the soluble IL-6R (sIL-6R) results in an agonistic IL-6/sIL-6R complex, which activates cells via gp130 irrespective of whether the cells express the IL-6R itself....

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Riethmueller, Steffen, Ehlers, Johanna C., Lokau, Juliane, Düsterhöft, Stefan, Knittler, Katharina, Dombrowsky, Gregor, Grötzinger, Joachim, Rabe, Björn, Rose-John, Stefan, Garbers, Christoph
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858764/
https://ncbi.nlm.nih.gov/pubmed/27151651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25550
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