Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However, approximately 4% of all humans carry a homozygous deletion of the gene that encodes NKG2C (NKG2C(−/−)). Assessment of NK cell repertoires in 60 NKG2...

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Pubblicato in:Cell Rep
Autori principali: Liu, Lisa L., Landskron, Johannes, Ask, Eivind H., Enqvist, Monika, Sohlberg, Ebba, Traherne, James A., Hammer, Quirin, Goodridge, Jodie P., Larsson, Stella, Jayaraman, Jyothi, Oei, Vincent Y.S., Schaffer, Marie, Taskén, Kjetil, Ljunggren, Hans-Gustaf, Romagnani, Chiara, Trowsdale, John, Malmberg, Karl-Johan, Béziat, Vivien
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858565/
https://ncbi.nlm.nih.gov/pubmed/27117418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.005
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