Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However, approximately 4% of all humans carry a homozygous deletion of the gene that encodes NKG2C (NKG2C(−/−)). Assessment of NK cell repertoires in 60 NKG2...

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Udgivet i:Cell Rep
Main Authors: Liu, Lisa L., Landskron, Johannes, Ask, Eivind H., Enqvist, Monika, Sohlberg, Ebba, Traherne, James A., Hammer, Quirin, Goodridge, Jodie P., Larsson, Stella, Jayaraman, Jyothi, Oei, Vincent Y.S., Schaffer, Marie, Taskén, Kjetil, Ljunggren, Hans-Gustaf, Romagnani, Chiara, Trowsdale, John, Malmberg, Karl-Johan, Béziat, Vivien
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858565/
https://ncbi.nlm.nih.gov/pubmed/27117418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.005
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