Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However, approximately 4% of all humans carry a homozygous deletion of the gene that encodes NKG2C (NKG2C(−/−)). Assessment of NK cell repertoires in 60 NKG2...

Full description

Saved in:
Bibliographic Details
Published in:Cell Rep
Main Authors: Liu, Lisa L., Landskron, Johannes, Ask, Eivind H., Enqvist, Monika, Sohlberg, Ebba, Traherne, James A., Hammer, Quirin, Goodridge, Jodie P., Larsson, Stella, Jayaraman, Jyothi, Oei, Vincent Y.S., Schaffer, Marie, Taskén, Kjetil, Ljunggren, Hans-Gustaf, Romagnani, Chiara, Trowsdale, John, Malmberg, Karl-Johan, Béziat, Vivien
Format: Artigo
Language:Inglês
Published: Cell Press 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858565/
https://ncbi.nlm.nih.gov/pubmed/27117418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.005
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items