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Resolving individual steps of Okazaki fragment maturation at msec time-scale
DNA polymerase delta (Pol δ) is responsible for elongation and maturation of Okazaki fragments. Pol δ and flap-endonuclease FEN1, coordinated by the PCNA clamp, remove RNA primers and produce ligatable nicks. We have studied this process with the Saccharomyces cerevisiae machinery at msec resolution...
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| Veröffentlicht in: | Nat Struct Mol Biol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4857878/ https://ncbi.nlm.nih.gov/pubmed/27065195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3207 |
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