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Sequential switching of binding partners on PCNA during in vitro Okazaki fragment maturation

The homotrimeric sliding clamp proliferating cell nuclear antigen (PCNA) mediates Okazaki fragment maturation through tight coordination of the activities of DNA polymerase δ (Pol δ), flap endonuclease 1 (FEN1) and DNA ligase I (Lig1). Little is known regarding the mechanism of partner switching on...

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Main Authors: Dovrat, Daniel, Stodola, Joseph L., Burgers, Peter M. J., Aharoni, Amir
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191785/
https://ncbi.nlm.nih.gov/pubmed/25228764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321349111
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