An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s

AIM: The substrate cocktail is frequently used to evaluate cytochrome P450 (CYP) enzyme-mediated drug interactions and potential interactions among the probe substrates. Here, we re-optimized the substrate cocktail method to increase the reliability and accuracy of screening for candidate compounds...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Chen, Zhong-hua, Zhang, Su-xing, Long, Na, Lin, Li-shan, Chen, Tao, Zhang, Fei-peng, Lv, Xue-qin, Ye, Pei-zhen, Li, Ning, Zhang, Ke-zhi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4857547/
https://ncbi.nlm.nih.gov/pubmed/27063220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.10
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