An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes

An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450 (CYP) enzymes. This method employed a cocktail of six probe substrates (i.e., phenacetin, amodiaquine, diclofenac, S-mephenytoin, dextromethorphan a...

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Vydáno v:J Pharm Anal
Hlavní autoři: Wang, Jing-Jing, Guo, Jian-Jun, Zhan, Jenny, Bu, Hai-Zhi, Lin, Jiunn H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Xi'an Jiaotong University 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761213/
https://ncbi.nlm.nih.gov/pubmed/29403890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2014.01.001
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