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Inactive mutants of human pyridoxine 5′‐phosphate oxidase: a possible role for a noncatalytic pyridoxal 5′‐phosphate tight binding site

Pyridoxal 5′‐phosphate (PLP) is a cofactor for many vitamin B6‐requiring enzymes that are important for the synthesis of neurotransmitters. Pyridoxine 5′‐phosphate oxidase (PNPO) is one of two enzymes that produce PLP. Some 16 known mutations in human PNPO (hPNPO), including R95C and R229W, lead to...

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Publicat a:FEBS Open Bio
Autors principals: Ghatge, Mohini S., Karve, Sayali S., David, Tanya M. S., Ahmed, Mostafa H., Musayev, Faik N., Cunningham, Kendra, Schirch, Verne, Safo, Martin K.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856418/
https://ncbi.nlm.nih.gov/pubmed/27419045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12042
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