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Inactive mutants of human pyridoxine 5′‐phosphate oxidase: a possible role for a noncatalytic pyridoxal 5′‐phosphate tight binding site

Pyridoxal 5′‐phosphate (PLP) is a cofactor for many vitamin B6‐requiring enzymes that are important for the synthesis of neurotransmitters. Pyridoxine 5′‐phosphate oxidase (PNPO) is one of two enzymes that produce PLP. Some 16 known mutations in human PNPO (hPNPO), including R95C and R229W, lead to...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:FEBS Open Bio
Egile Nagusiak: Ghatge, Mohini S., Karve, Sayali S., David, Tanya M. S., Ahmed, Mostafa H., Musayev, Faik N., Cunningham, Kendra, Schirch, Verne, Safo, Martin K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856418/
https://ncbi.nlm.nih.gov/pubmed/27419045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12042
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