Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition

Several drugs and natural compounds are known to be highly neurotoxic, triggering epileptic convulsions or seizures, and causing headaches, agitations, as well as other neuronal symptoms. The neurotoxic effects of some of these compounds, including theophylline and ginkgotoxin, have been traced to t...

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Autores principales: Gandhi, Amit K., Desai, Jigar V., Ghatge, Mohini S., di Salvo, Martino L., Di Biase, Stefano, Danso-Danquah, Richmond, Musayev, Faik N., Contestabile, Roberto, Schirch, Verne, Safo, Martin K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412620/
https://ncbi.nlm.nih.gov/pubmed/22879864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040954
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