High-resolution mass spectrometry of small molecules bound to membrane proteins

Small molecules are known to stabilise membrane proteins and to modulate function and oligomeric state, but their identity is often hard to define. Here we develop and apply a high-resolution, Orbitrap mass spectrometer for intact membrane protein-ligand complexes. Using this platform we resolve the...

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Detalhes bibliográficos
Publicado no:Nat Methods
Main Authors: Gault, Joseph, Donlan, Joseph A. C., Liko, Idlir, Hopper, Jonathan T.S., Gupta, Kallol, Housden, Nicholas G., Struwe, Weston B., Marty, Michael T., Mize, Todd, Bechara, Cherine, Zhu, Ya, Wu, Beili, Kleanthous, Colin, Belov, Mikhail, Damoc, Eugen, Makarov, Alexander, Robinson, Carol V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856209/
https://ncbi.nlm.nih.gov/pubmed/26901650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3771
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