High-resolution mass spectrometry of small molecules bound to membrane proteins

Small molecules are known to stabilise membrane proteins and to modulate function and oligomeric state, but their identity is often hard to define. Here we develop and apply a high-resolution, Orbitrap mass spectrometer for intact membrane protein-ligand complexes. Using this platform we resolve the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Methods
Prif Awduron: Gault, Joseph, Donlan, Joseph A. C., Liko, Idlir, Hopper, Jonathan T.S., Gupta, Kallol, Housden, Nicholas G., Struwe, Weston B., Marty, Michael T., Mize, Todd, Bechara, Cherine, Zhu, Ya, Wu, Beili, Kleanthous, Colin, Belov, Mikhail, Damoc, Eugen, Makarov, Alexander, Robinson, Carol V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856209/
https://ncbi.nlm.nih.gov/pubmed/26901650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3771
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